The concomitant usage of opioids with other medications that impact the serotonergic neurotransmitter process has resulted in serotonin syndrome.
Promethazine HCl and Codeine Phosphate Oral Option may perhaps lead to severe hypotension like orthostatic hypotension and syncope in ambulatory patients. There exists enhanced threat in patients whose skill to maintain blood pressure has already been compromised by a lowered blood volume or concurrent administration of particular CNS depressant medicines (e.
Lively and prophylactic remedy of motion sickness. Antiemetic therapy in postoperative sufferers.
Postmarketing circumstances of respiratory depression, which include fatalities, are noted with usage of Promethazine in pediatric individuals lower than 2 yrs of age. A wide range of body weight-dependent doses of Promethazine have resulted in respiratory depression in these individuals.
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Head Personal injury And Amplified Intracranial Tension: The respiratory-depressant consequences of narcotic analgesics and their ability to elevate cerebrospinal fluid stress could be markedly exaggerated within the presence of head personal injury, intracranial lesions or even a preexisting boost in intracranial pressure.
Promethazine HCl and Codeine Phosphate Oral Option must be made use of with caution in patients with bone- marrow melancholy. Leukopenia and agranulocytosis have already been documented, commonly when promethazine continues to be Employed in association with other acknowledged marrow-harmful brokers.
Promethazine HCl and Codeine Phosphate Oral Resolution is indicated for the short term aid of coughs and higher respiratory signs or symptoms related to allergy or even the typical chilly in patients 18 years of age and older.
Lower blood pressure. A unexpected fall in blood pressure can materialize in lots of people through remedy with Promethazine Hydrochloride and Codeine Phosphate Oral Answer which could cause you to definitely feel dizzy, faint, lightheaded, or weak, particularly when you rise up (orthostatic hypotension). Your chance of getting this problem can be improved if you are taking Promethazine Hydrochloride and Codeine Phosphate Oral Answer with selected other medicines that reduce blood pressure level.
Abuse and addiction are independent and distinct from Bodily dependence and tolerance. Overall health treatment suppliers need to be aware that addiction might not be accompanied by concurrent tolerance and signs of Bodily dependence in all addicts. Moreover, abuse of opioids can come about from the absence of legitimate dependancy.
Prevent using Promethazine HCl and Codeine Phosphate Oral Alternative in adolescents 12 to 18 decades of age who have other hazard elements that could maximize their sensitivity to the respiratory depressant effects of codeine Except if the benefits check here outweigh the hazards.
Sedating prescription drugs might lead to confusion and over-sedation during the aged; aged patients typically really should be started on minimal doses of Promethazine Hydrochloride and Codeine Phosphate Syrup and observed carefully.
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Promethazine Indicators and signs and symptoms of overdosage with promethazine range between delicate depression from the central anxious technique and cardiovascular program to profound hypotension, respiratory depression, unconsciousness and unexpected Loss of life.